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	<title>Comments on: Houston&#8217;s Dearth of Biotech Entrepreneurship</title>
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	<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/</link>
	<description>bridging science and business</description>
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		<title>By: Graham</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-192</link>
		<dc:creator>Graham</dc:creator>
		<pubDate>Thu, 26 Mar 2009 14:14:56 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-192</guid>
		<description>Thanks for visiting the site, Robert. I see from your bio that you&#039;re a biotech entrepreneur who has started companies across the country, but never in Houston. Out of curiosity, has Houston ever shown up on your radar? From an outsider&#039;s perspective, what would it take to get someone with your experience to start a company in Houston? What do you think we&#039;re missing?</description>
		<content:encoded><![CDATA[<p>Thanks for visiting the site, Robert. I see from your bio that you&#8217;re a biotech entrepreneur who has started companies across the country, but never in Houston. Out of curiosity, has Houston ever shown up on your radar? From an outsider&#8217;s perspective, what would it take to get someone with your experience to start a company in Houston? What do you think we&#8217;re missing?</p>
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		<title>By: Robert Nowinski</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-190</link>
		<dc:creator>Robert Nowinski</dc:creator>
		<pubDate>Thu, 26 Mar 2009 13:07:12 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-190</guid>
		<description>It is certainly a wonder - with Houston&#039;s large population and universities such as Rice - why Houston doesn&#039;t have a larger biotech presence.</description>
		<content:encoded><![CDATA[<p>It is certainly a wonder &#8211; with Houston&#8217;s large population and universities such as Rice &#8211; why Houston doesn&#8217;t have a larger biotech presence.</p>
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		<title>By: Michael Dilling</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-132</link>
		<dc:creator>Michael Dilling</dc:creator>
		<pubDate>Wed, 22 Oct 2008 13:41:29 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-132</guid>
		<description>Graham, you raise a good point. I believe that leadership and business skills can certainly translate from one industry to another. Rick Barsky, the CEO of Agennix, provides such an example.  The challenge is that it can be very difficult to move from one local biotech company to another - if a company fails, the executive will likely have to switch industries or move to another city. I know some folks who have been displaced by recent events in the local biotech community and it creates a very difficult situation for them. 

I agree, we probably aren&#039;t going to see any sort of big pharma presence in Houston in the near term future.  The economy will recover, although it remains to be seen what will happen in the pharma industry - if government forays into healthcare result in the institution of drug price controls, etc., who knows what will happen. 

We live in interesting times, to be sure.</description>
		<content:encoded><![CDATA[<p>Graham, you raise a good point. I believe that leadership and business skills can certainly translate from one industry to another. Rick Barsky, the CEO of Agennix, provides such an example.  The challenge is that it can be very difficult to move from one local biotech company to another &#8211; if a company fails, the executive will likely have to switch industries or move to another city. I know some folks who have been displaced by recent events in the local biotech community and it creates a very difficult situation for them. </p>
<p>I agree, we probably aren&#8217;t going to see any sort of big pharma presence in Houston in the near term future.  The economy will recover, although it remains to be seen what will happen in the pharma industry &#8211; if government forays into healthcare result in the institution of drug price controls, etc., who knows what will happen. </p>
<p>We live in interesting times, to be sure.</p>
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		<title>By: Graham</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-131</link>
		<dc:creator>Graham</dc:creator>
		<pubDate>Mon, 20 Oct 2008 20:52:15 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-131</guid>
		<description>Michael, thank you for your comments.  A couple of months ago, I had coffee with Mike Lowe, CEO of OrthoAccel, and this topic of experienced management came up. Mike asked, &quot;Why can&#039;t we tap into the experienced management in all the energy companies here in Houston?&quot; That&#039;s an interesting question. Houston is home to more Fortune 500 companies than any other U.S. city, save for New York. We&#039;ve got lots of experienced business talent, they&#039;re just in different industries. And, importantly, they have much deeper ties to Houston.

Sure, ideally, we&#039;d want experienced Big Pharma executives, but a lot of leadership and business skills will translate. The big energy companies in town do a great job of executive development. They move their stars around so that they get exposure and experience in multiple aspects of business. Many of them could adapt quickly to leadership roles in life sciences startups.

The big question is: how many of these execs would be willing to take a chance on a life sciences startup? There probably aren&#039;t many, but how many do we need? Given where we are, if we could place 10 Houston execs in leadership positions at life science startups, wouldn&#039;t that make a difference? Maybe this economic downturn will set a couple of these executives free?

It&#039;s something to consider. Given the number of layoffs in the pharma industry these days, I&#039;m not going to hold my breath for a large R&amp;D facility to be built here.</description>
		<content:encoded><![CDATA[<p>Michael, thank you for your comments.  A couple of months ago, I had coffee with Mike Lowe, CEO of OrthoAccel, and this topic of experienced management came up. Mike asked, &#8220;Why can&#8217;t we tap into the experienced management in all the energy companies here in Houston?&#8221; That&#8217;s an interesting question. Houston is home to more Fortune 500 companies than any other U.S. city, save for New York. We&#8217;ve got lots of experienced business talent, they&#8217;re just in different industries. And, importantly, they have much deeper ties to Houston.</p>
<p>Sure, ideally, we&#8217;d want experienced Big Pharma executives, but a lot of leadership and business skills will translate. The big energy companies in town do a great job of executive development. They move their stars around so that they get exposure and experience in multiple aspects of business. Many of them could adapt quickly to leadership roles in life sciences startups.</p>
<p>The big question is: how many of these execs would be willing to take a chance on a life sciences startup? There probably aren&#8217;t many, but how many do we need? Given where we are, if we could place 10 Houston execs in leadership positions at life science startups, wouldn&#8217;t that make a difference? Maybe this economic downturn will set a couple of these executives free?</p>
<p>It&#8217;s something to consider. Given the number of layoffs in the pharma industry these days, I&#8217;m not going to hold my breath for a large R&#038;D facility to be built here.</p>
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		<title>By: Michael Dilling</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-130</link>
		<dc:creator>Michael Dilling</dc:creator>
		<pubDate>Mon, 20 Oct 2008 17:49:48 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-130</guid>
		<description>Very interesting and provocative site Graham. Having been a part of the university tech transfer scene here in Texas Medical Center for about the past nine years, I think that in order to meaningfully accelerate the rate of biotech commercialization here in Houston, we need an infusion of experienced talent.  With the acquisitions of Tanox and Encysive and the downsizing of Lexicon, I&#039;m confident that our local biotech community has lost some experienced talent over the past year or so. Those folks will go wherever the opportunities are. If you are employed at a local biotech company and you lose your job, it can be very difficult to find another job at a local company. 

Investors like to invest in companies that are being run by management who has &quot;been there, done that&quot;, and the pool of local individuals who can lay claim to successfully commercializing drugs/vaccines/therapeutics is just not that deep. The device arena is a little different - there is more depth there.

I&#039;ve heard the oft-repeated mantra that local academic institutions need to &quot;do more&quot; to stimulate technology commercialization.  That may well be true (although I think the Rice Alliance is doing an outstanding job as it is), but the local academic institutions are only a part of the local innovation ecosystem.  A number of years ago, our institution was under pressure to &quot;start more companies&quot; because that was going to be the route by which we could &quot;catch up&quot; to the Bostons and San Diegos of the world.  The act of starting companies in and of itself won&#039;t address the problem if many of the companies end up being undercapitalized and can&#039;t successfully advance their technologies. 

I really think that in order to catalyze the next &quot;leap forward&quot;, a mechanism needs to be found to bring in more experienced human capital. There has been talk of trying to lure a pharma R&amp;D presence to the Houston area, but I&#039;m not sure about the level of resources that have been committed to such an effort. 

Of course, we&#039;re all going to have to wait out the current bout of economic turmoil before we can worry too much about trying to grow the local biotech industry.</description>
		<content:encoded><![CDATA[<p>Very interesting and provocative site Graham. Having been a part of the university tech transfer scene here in Texas Medical Center for about the past nine years, I think that in order to meaningfully accelerate the rate of biotech commercialization here in Houston, we need an infusion of experienced talent.  With the acquisitions of Tanox and Encysive and the downsizing of Lexicon, I&#8217;m confident that our local biotech community has lost some experienced talent over the past year or so. Those folks will go wherever the opportunities are. If you are employed at a local biotech company and you lose your job, it can be very difficult to find another job at a local company. </p>
<p>Investors like to invest in companies that are being run by management who has &#8220;been there, done that&#8221;, and the pool of local individuals who can lay claim to successfully commercializing drugs/vaccines/therapeutics is just not that deep. The device arena is a little different &#8211; there is more depth there.</p>
<p>I&#8217;ve heard the oft-repeated mantra that local academic institutions need to &#8220;do more&#8221; to stimulate technology commercialization.  That may well be true (although I think the Rice Alliance is doing an outstanding job as it is), but the local academic institutions are only a part of the local innovation ecosystem.  A number of years ago, our institution was under pressure to &#8220;start more companies&#8221; because that was going to be the route by which we could &#8220;catch up&#8221; to the Bostons and San Diegos of the world.  The act of starting companies in and of itself won&#8217;t address the problem if many of the companies end up being undercapitalized and can&#8217;t successfully advance their technologies. </p>
<p>I really think that in order to catalyze the next &#8220;leap forward&#8221;, a mechanism needs to be found to bring in more experienced human capital. There has been talk of trying to lure a pharma R&amp;D presence to the Houston area, but I&#8217;m not sure about the level of resources that have been committed to such an effort. </p>
<p>Of course, we&#8217;re all going to have to wait out the current bout of economic turmoil before we can worry too much about trying to grow the local biotech industry.</p>
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		<title>By: University of Houston Vies to be Tier 1 &#8212; graham randall, ph.d, mba</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-57</link>
		<dc:creator>University of Houston Vies to be Tier 1 &#8212; graham randall, ph.d, mba</dc:creator>
		<pubDate>Mon, 28 Jul 2008 11:54:33 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-57</guid>
		<description>[...] heard some people blame Houston&#8217;s lack of a biotech cluster on the fact that the University of Houston isn&#8217;t a tier 1 school like UT Austin and Texas [...]</description>
		<content:encoded><![CDATA[<p>[...] heard some people blame Houston&#8217;s lack of a biotech cluster on the fact that the University of Houston isn&#8217;t a tier 1 school like UT Austin and Texas [...]</p>
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		<title>By: David</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-56</link>
		<dc:creator>David</dc:creator>
		<pubDate>Sun, 27 Jul 2008 21:39:16 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-56</guid>
		<description>I mean send out flyers in texas, not just houston.  ut, am smu, rice, ttu etc...</description>
		<content:encoded><![CDATA[<p>I mean send out flyers in texas, not just houston.  ut, am smu, rice, ttu etc&#8230;</p>
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		<title>By: David</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-55</link>
		<dc:creator>David</dc:creator>
		<pubDate>Sun, 27 Jul 2008 21:37:07 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-55</guid>
		<description>I don&#039; know.  I guess we could call up goldman sachs and ask those guys to do whatever it is they do.  
Internally I guess the faculty could implement weekly meetings to discuss this as a group, set goals depending on conversations with a financial sector, and then get some shiznit done.

Either way I think dialogue is important.  This is the starting point.  Naturally with a group of smart people good ideas will be born.  If commercializing is an issue and receiving money to support growth is a goal then maybe we should call up the Houston Chronicle and ask if we could rent out  a section dedicated to current, promising  technology just so the public can read this and keep up.  I&#039;m sure there are a bunch of nerds in Houston who would hone an interest in this.  With dialogue on both fronts, intra and internally, the buzz probably would allow some things to happen.
Either way you guys need to get dedicated scientists  like me working in an area like the biotech companies so they won&#039;t bust.  I really don&#039;t want to work at a university where you have uncommitted workers dragging their ass in at 1030 am and basically wasting  materials (i.e. Western blot buffers since it is likely your blots won&#039;t develop b/c you were too mind distracted to insert the correct plasmid you needed, with the antibody codon inserted  into your competant cells to begin with) where I could get to work in a lab that&#039;s serious.  Problem is that every time I try to find a job in the biotech company area, it seems either their labs are in New Mexico or they move after 4-5 months.  What the H yo?  Hey it&#039;s a 2 way street, if youre a solid company in houston and you want talent then send out flyers to all grad programs in houston so we can know where the heck you guys are.  I really don&#039;t want to go to law school and do &quot;IP law&quot;.  TMC put up some biotech info on your website  so people like me can know what specific areas you need work.  Ridiculous yo.</description>
		<content:encoded><![CDATA[<p>I don&#8217; know.  I guess we could call up goldman sachs and ask those guys to do whatever it is they do.<br />
Internally I guess the faculty could implement weekly meetings to discuss this as a group, set goals depending on conversations with a financial sector, and then get some shiznit done.</p>
<p>Either way I think dialogue is important.  This is the starting point.  Naturally with a group of smart people good ideas will be born.  If commercializing is an issue and receiving money to support growth is a goal then maybe we should call up the Houston Chronicle and ask if we could rent out  a section dedicated to current, promising  technology just so the public can read this and keep up.  I&#8217;m sure there are a bunch of nerds in Houston who would hone an interest in this.  With dialogue on both fronts, intra and internally, the buzz probably would allow some things to happen.<br />
Either way you guys need to get dedicated scientists  like me working in an area like the biotech companies so they won&#8217;t bust.  I really don&#8217;t want to work at a university where you have uncommitted workers dragging their ass in at 1030 am and basically wasting  materials (i.e. Western blot buffers since it is likely your blots won&#8217;t develop b/c you were too mind distracted to insert the correct plasmid you needed, with the antibody codon inserted  into your competant cells to begin with) where I could get to work in a lab that&#8217;s serious.  Problem is that every time I try to find a job in the biotech company area, it seems either their labs are in New Mexico or they move after 4-5 months.  What the H yo?  Hey it&#8217;s a 2 way street, if youre a solid company in houston and you want talent then send out flyers to all grad programs in houston so we can know where the heck you guys are.  I really don&#8217;t want to go to law school and do &#8220;IP law&#8221;.  TMC put up some biotech info on your website  so people like me can know what specific areas you need work.  Ridiculous yo.</p>
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		<title>By: Graham</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-53</link>
		<dc:creator>Graham</dc:creator>
		<pubDate>Sun, 27 Jul 2008 15:06:21 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-53</guid>
		<description>Thanks for your comments, David. I absolutely agree with you that mixing science and commercialization is &quot;a fine balancing act.&quot;  We don&#039;t want to turn all of our scientists into Armani-wearing Forbes readers. We want them thinking about science and how to advance technology. 

We also want them thinking about how they can get their technology out of the lab and into the clinics. The evidence -- in terms of number of startup companies, VC deals, biotech employees, etc. -- shows that Houston scientists, unlike their peers, are not that making the leap from invention to commercialization. That&#039;s why Houston is out of balance. Compared to our peers, San Francisco, San Diego, and Boston, Houston just isn&#039;t commercializing technology at the same rate.

What solution would you propose that gets Houston&#039;s technology out of the lab and into the clinic?  

(By the way, if you intended your comments for Eric Berger, his blog is available &lt;a href=&quot;http://blogs.chron.com/sciguy/archives/2008/07/is_houstons_bio.html&quot; rel=&quot;nofollow&quot;&gt;here&lt;/a&gt;)</description>
		<content:encoded><![CDATA[<p>Thanks for your comments, David. I absolutely agree with you that mixing science and commercialization is &#8220;a fine balancing act.&#8221;  We don&#8217;t want to turn all of our scientists into Armani-wearing Forbes readers. We want them thinking about science and how to advance technology. </p>
<p>We also want them thinking about how they can get their technology out of the lab and into the clinics. The evidence &#8212; in terms of number of startup companies, VC deals, biotech employees, etc. &#8212; shows that Houston scientists, unlike their peers, are not that making the leap from invention to commercialization. That&#8217;s why Houston is out of balance. Compared to our peers, San Francisco, San Diego, and Boston, Houston just isn&#8217;t commercializing technology at the same rate.</p>
<p>What solution would you propose that gets Houston&#8217;s technology out of the lab and into the clinic?  </p>
<p>(By the way, if you intended your comments for Eric Berger, his blog is available <a href="http://blogs.chron.com/sciguy/archives/2008/07/is_houstons_bio.html" rel="nofollow">here</a>)</p>
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		<title>By: david</title>
		<link>http://grandall.org/2008/07/13/houstons-dearth-of-biotech-entrepreneurship/comment-page-1/#comment-52</link>
		<dc:creator>david</dc:creator>
		<pubDate>Sun, 27 Jul 2008 13:21:54 +0000</pubDate>
		<guid isPermaLink="false">http://grandall.org/?p=19#comment-52</guid>
		<description>Hello  Mr. Berger:
I found your article really interesting and agree that Houston aught to make a push to commercialize legitimate technology in regards to serving medicinal progress.  And yes considering that the TMC is the only institution of it&#039;s caliber in this southern region your information does logically fit in this mix, (just my opinion).
However, I think that some of the data that you  have and the tone you present might be misleading.  Yes there may be slightly more PhD&#039;s graduating w/ the same amount of tenure jobs...but this may not be a big problem.  Some go back to their countries.  There are many medical universities who would love to have PhD scientists drive their research.  Baylor, MD Anderson...etc..., and not on the professor track.  I&#039;d say the jobs are competitive yes...but not so cutthroat to influence an entire wave of new PhD&#039;s  to jump on the biopharma bandwagon.  A portion of those folks probably just want to make that extra buck....
which is a problem.  there is a fine balance with this topic.  I personally would not want to see TMC turn into the dark tower of corporate houston.  as far as im concerned a lot of good research is going on there...and i can just smell future success on the level of discovery.  and although your analysis does prompt administrators to act entrepreneurially, the last thing we need is our scientists to come to work in armani suits and discussing the latest article  in &quot;Forbes&quot; instead of &quot;Cell&quot;.

I&#039;d hate for this to be one big propaganda act by some business majors to just make a quick buck.  Don&#039;t worry we&#039;ll come up with something for you boys to do</description>
		<content:encoded><![CDATA[<p>Hello  Mr. Berger:<br />
I found your article really interesting and agree that Houston aught to make a push to commercialize legitimate technology in regards to serving medicinal progress.  And yes considering that the TMC is the only institution of it&#8217;s caliber in this southern region your information does logically fit in this mix, (just my opinion).<br />
However, I think that some of the data that you  have and the tone you present might be misleading.  Yes there may be slightly more PhD&#8217;s graduating w/ the same amount of tenure jobs&#8230;but this may not be a big problem.  Some go back to their countries.  There are many medical universities who would love to have PhD scientists drive their research.  Baylor, MD Anderson&#8230;etc&#8230;, and not on the professor track.  I&#8217;d say the jobs are competitive yes&#8230;but not so cutthroat to influence an entire wave of new PhD&#8217;s  to jump on the biopharma bandwagon.  A portion of those folks probably just want to make that extra buck&#8230;.<br />
which is a problem.  there is a fine balance with this topic.  I personally would not want to see TMC turn into the dark tower of corporate houston.  as far as im concerned a lot of good research is going on there&#8230;and i can just smell future success on the level of discovery.  and although your analysis does prompt administrators to act entrepreneurially, the last thing we need is our scientists to come to work in armani suits and discussing the latest article  in &#8220;Forbes&#8221; instead of &#8220;Cell&#8221;.</p>
<p>I&#8217;d hate for this to be one big propaganda act by some business majors to just make a quick buck.  Don&#8217;t worry we&#8217;ll come up with something for you boys to do</p>
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